Division of Nuclear Medicine
300 Longwood Avenue
Boston, MA 02115
Telephone Number: 617 355-7010
Fax Number: 617 264-9536

S. T. TREVES, M.D.
treves@tch.harvard.edu
617 355-7935 (Children's Hospital)
617 732-6290 (Brigham and Women's Hospital)
Also available to mentor research at Brigham and Women's Hospital

Interests:

• Comparison of planar 99mTc-DMSA renal scintigraphy and SPECT (sum of coronal slices and volume rendering) for the diagnosis of renal cortical defects (a prospective study).

A.B. Packard, PH.D.
packard@a1.tch.harvard.edu
617 355-7539

Interests:

• Cu-64-based PET radiopharmaceuticals for measuring multidrug-resistance.Ê The focus of this project is the synthesis of new copper ligands that can be used to prepare Cu-64 complexes with biological properties similar to those of existing single-photon compounds that are substrates for Pgp and MRP1, the proteins responsible for multidrug resistance.Ê The project involves the synthesis and characterization of new ligands, the synthesis and characterization of the non-radioactive and Cu-64 complexes, and the measurement of the biological properties of the Cu-64 complexes in vitro and in vivo.
• Evaluation of new radiopharmaceuticals for measuring response to anti angiogenesis therapy. The focus of this project is the evaluation, in animal models, of how the tumor uptake of radiopharmaceuticals that target receptors, such as avb3, which are expressed in neovasculature, changes in response to anti-angiogenesis therapy. These changes would provide a direct way to measure clinical response to new anti-angiogenesis agents.

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